FOXO4-DRI (Proxofim) 10mg
CAS: N/A
FOXO4 DRI 10 mg Proxofim by Biopeptides is a cutting-edge research peptide designed for advanced studies in cellular senescence, apoptosis, and aging biology. Trusted by laboratories across Europe, including Germany, France, Italy, Spain, and the Netherlands, this high-purity peptide provides reliable results for preclinical research. Ideal for exploring senescent cell removal, p53-mediated apoptosis, and tissue regeneration mechanisms, FOXO4 DRI supports meaningful scientific discoveries. Biopeptides delivers top-quality peptides for researchers who want to buy peptides online with confidence. Unlock the potential of your laboratory studies with FOXO4 DRI, one of the best peptides for modern molecular biology research.
$395.00
Research Use Only
FOXO4-DRI Research Peptide Overview
FOXO4-DRI (Proxofim) from Biopeptides is a laboratory-grade synthetic peptide developed specifically for scientific research into cellular senescence and aging biology.
This peptide is engineered to disrupt the interaction between the transcription factor FOXO4 and the tumor suppressor protein p53, a key regulatory pathway involved in senescent cell survival.
By enabling controlled disruption of this interaction in experimental models, FOXO4-DRI allows researchers to investigate apoptosis signaling and cellular aging mechanisms.
Scientific Background of FOXO4-DRI
FOXO4 belongs to the FOXO family of transcription factors responsible for regulating cellular stress responses, metabolism, and survival signaling.
In senescent cells, FOXO4 binds to the tumor suppressor protein p53 and prevents it from initiating apoptosis.
FOXO4-DRI was designed to disrupt this interaction, allowing p53 to activate programmed cell death in senescent cells during laboratory studies.
This mechanism provides a valuable research model for investigating aging biology, cell-cycle regulation, and the role of senescent cells in tissue function.
Mechanistic Research Perspective
- Disruption of FOXO4–p53 protein interaction
- Activation of p53-mediated apoptosis pathways
- Modeling senescent cell survival and removal mechanisms
- Analysis of transcription-factor signaling networks
- Investigation of age-related cellular stress responses
Primary Research Applications
Cellular Senescence Studies: FOXO4-DRI is widely used in experimental models to investigate how senescent cells accumulate and influence tissue function.
Apoptosis Signaling Research: Supports studies exploring programmed cell death pathways and p53-mediated apoptosis in aging or damaged cells.
Aging Biology and Longevity Research: Used in controlled laboratory experiments to analyze mechanisms associated with cellular aging and regenerative processes.
Inflammation and SASP Investigations: Allows researchers to study the senescence-associated secretory phenotype (SASP) and its effects on tissue inflammation.
Transcription-Factor Pathway Analysis: Suitable for molecular experiments examining FOXO transcription factor signaling and gene regulation.
Molecular Characteristics
- Molecular Type: Synthetic retro-inverso peptide
- Structure: Linear peptide with D-amino acid configuration
- Research Name: FOXO4-DRI (Proxofim)
- Form: Lyophilized peptide powder
- Design: Derived from FOXO4 transcription-factor interaction sequence
- Stability: Enhanced resistance to enzymatic degradation
Stability Profile and Storage Recommendations
- Supplied as a lyophilized peptide for long-term storage stability
- Recommended storage temperature: −20°C
- Protect from humidity and direct light exposure
- Avoid repeated freeze–thaw cycles
- Reconstituted solutions remain stable for approximately 24–48 hours under refrigeration
Solubility and Reconstitution Options
- Sterile bacteriostatic water
- Buffered aqueous solutions
- Sterile saline solutions
- Phosphate-buffered saline (PBS)
- Analytical-grade laboratory buffers
Technical Specifications
product Name
FOXO4-DRI (Proxofim) 10mg
brand
Biopeptides
cas
N/A
purity
≥99% (HPLC validated)
unit Size
10 mg
form
Lyophilized powder
synthesis
Solid-Phase Peptide Synthesis (SPPS)
analytical
HPLC, Mass Spectrometry
molecular Structure
Retro-inverso synthetic peptide
stability
High when stored appropriately
Analytical Validation and Quality Assurance
- High-Performance Liquid Chromatography (HPLC) purity verification
- Mass Spectrometry molecular identity confirmation
- Batch-to-batch consistency validation
- Quality control testing for research reliability
- Analytical documentation available for laboratory records
Frequently Asked Questions
FOXO4-DRI is used in laboratory studies investigating cellular senescence, apoptosis signaling, and FOXO4–p53 interaction pathways.
It disrupts the interaction between the FOXO4 transcription factor and p53, allowing researchers to analyze apoptosis signaling in senescent cells.
The peptide enables investigation into the role of senescent cells in aging and tissue function, helping scientists study molecular pathways associated with longevity.
Store the lyophilized peptide at −20°C and protect it from moisture and light. Avoid repeated freeze–thaw cycles.
No. FOXO4-DRI is intended strictly for laboratory research and is not approved for clinical or therapeutic applications.